Regenerationof Cells and Muscle Tissue
Regenerationof Cells and Muscle Tissue
Theterm regeneration is used frequently in cell-science, and mostly inbiology, whereby it refers to the process of renewal, growth andrestoration of body cells. The procedure of regeneration is anindispensable one as it makes sure cells organisms are resilient tonatural fluctuations or any damage to the cells. In other words, theterm renewal/regeneration is used to refer to the‘morphogenic processes’which are branded by the ‘phenotypic plasticity’ of the muscles,which in turn allows multi-cellular creatures, the ability to repairor sustain their physiological and morphological states (Huang& Thesleff, 2013).
Regenerationof muscles and cells has been over time been labelled as a keyprocess, yet, it’s during the past 20 years several attempts havebeen made to try and uncover the causing mechanisms behind theregeneration phenomenon. Over time, the technology advancement and inthe medical sector has shed some light on the issue of muscle andcell technology, and how the development is applied to improve humanlife. Within the skeletal muscles, there are the satellite cells,which have great potential for self-renewal. The newly formed tissuesrequire new cells, which they gain through a process referred as cellproliferation. Formation of new tissues requires development of newcells, which follows the process below sourcecell-proliferation-growing cell population-, anddifferentiation of cell (Huang& Thesleff, 2013).
Thehuman body is made up of three types of muscles, namely skeletal,cardiac and smooth muscles. The skeletal muscles have the ability toregenerate and form new muscle tissues, while the smooth muscles hasthe greatest ability to regenerate. During the process ofregeneration of skeletal muscle, when a skeletal muscle is damaged,the nearby muscle is activated and becomes the sources of new muscletissues. On the other hand, the smooth muscles have the ability todivide and form new smooth muscles. When a muscle injury occurs, itcauses inflammation and releases a soluble compound which acts as astimulant to the surrounding smooth cells to undergo division andreplace the injured cells. This entrancing process of muscle and cellregeneration is also applicable within animal muscles and cells, andits contributions in processes such as limbregeneration in amphibianshave led to investigations by the researchers on the potential formammalian muscle to go through de-differentiation (Pietrzak,2008).
Theprocess of muscle and cell regeneration is impacted by differentfactors such as how well the muscle tissue is networked by the growthand development of blood vessels as well as how the muscles areinnervated by contact with nerves. Nerve stimulation is a key processduring muscle and cell regeneration. The knowledge of muscleregeneration has been applied and exploited in the therapeuticprocess. The development in cell and muscle regeneration has led tothe advancement in the aspect of muscle engineering, which has beenapplied in the treatment of injuries an disease through the use ofcell and molecular biology (Akiyoshi, Madoka & Kunihiro, 2014).
Despitethe breakthrough in aspects of cell regeneration and engineering, theprocess has been faced with numerous challenges such as microbiologycontamination, disease transmission delivery of unwanted cells,among other demerits has greatly hampered the success of theapplication of cell and muscle regeneration knowledge. One of themajor and key models of muscle regeneration that deserves moreconsideration due to its probable practical and theoreticalsignificance is the regeneration of the wound surface of bisected oramputated muscles (Huang& Thesleff, 2013).The process of muscle and cell regeneration remains an essentialprocess through the human and animal lives, as it has proofed to keepspecies alive.
Akiyoshi,U., Madoka, I., & Kunihiro, T. (2014). Roles of nonmyogenicmesenchymal progenitors in pathogenesis and regeneration of skeletalmuscle. FrontiersIn Physiology, 4/51-11.
Pietrzak,W. S. (2008). Musculoskeletaltissue regeneration: Biological materials and methods.Totowa, NJ: Humana Press.
Huang,G. T.-J., & Thesleff, I. (2013). Stemcells in craniofacial development and regeneration.Hoboken, N.J: Wiley-Blackwell.